IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is supplied in a precise 1mg / 3ml pre-filled research pen – the extended half-life analog of native IGF-1, widely regarded as the premier research compound for studying anabolic signaling, tissue hyperplasia, and prolonged mitogenic/growth-promoting pathways. Explore complementary growth hormone research compounds in our Ipamorelin Pen or GHRP-2 & CJC-1295 No DAC Pen for synergistic studies.

IGF-1 LR3 is a modified recombinant analog of human IGF-1 featuring:

• Substitution of Arginine for Glutamic Acid at position 3 (R3), dramatically reducing binding to IGF-binding proteins (IGFBPs)
• Addition of a 13-amino acid extension at the N-terminus, further decreasing affinity for IGFBPs and increasing biological half-life to 20–30 hours (compared to ~10–20 minutes for native IGF-1)

These structural changes allow IGF-1 LR3 to remain active in circulation significantly longer, providing sustained activation of the IGF-1 receptor (IGF-1R) and downstream PI3K/Akt/mTOR and MAPK pathways.

Core research applications include:

• Potent stimulation of skeletal muscle cell proliferation (hyperplasia) and satellite cell activation
• Enhanced protein synthesis, nitrogen retention, and anabolic cellular responses
• Investigation of localized vs. systemic growth promotion and tissue-specific effects
• Accelerated recovery, repair, and regeneration of muscle, tendon, ligament, and connective tissue
• Modulation of body composition: increased lean mass with minimal water retention in many models
• Studies on anti-catabolic effects, glucose uptake in muscle (independent of insulin), and potential neuroprotective/neurogenic properties
• Exploration of IGF-1 receptor signaling in cancer biology, aging, and metabolic regulation (with appropriate controls)

The 1mg strength in a 3ml pen delivers excellent volume flexibility for micro-dosing, site-specific administration protocols, or experiments requiring precise low-to-moderate exposure levels while maintaining the compound’s signature prolonged action.

Product highlights:

• Exceptional purity IGF-1 LR3 (>98.5% – third-party HPLC & MS verified)
• Sterile, ready-to-use pre-filled pen injector – accurate dosing and maximum laboratory convenience
• Extended half-life formulation for sustained pathway activation in research settings

What’s included:

• Reusable precision peptide pen injector
• Pre-filled IGF-1 LR3 solution (1mg / 3ml)
• Detailed usage instructions
• 10 sterile, single-use needles